Mechanically-induced solvent-less synthesis of cobalt and nickel complexes of cimetidine

Adedibu Clement Tella, Uche B. Eke, Aaron Y. Isaac, Christianah A. Ojekanmi

Abstract


Solvent-less synthesis of [Co(CIM)2](SO4) and [Ni(CIM)2](OAC)2 by grinding of CoSO4 and Ni(CH3COO)2.4H2O with cimetidine without any solvent is described. The complexes have been characterized by elemental analysis, melting point, AAS, conductivity measurements, TLC, infrared and UV-Vis spectroscopies as well as X-ray powder diffraction. Cimetidine was found to be bidentate or tridentate ligand. Cobalt ion coordinate with cimetidine through the sulphur atom in the thiol group, nitrogen atom of imidazole ring and the nitrogen atom of the secondary amine to give an octahedral geometry with ligand acting as tridentate whereas nickel ion coordinates through the sulphur atom in the thiol group, nitrogen atom of imidazole ring to give tetrahedral structure with ligand acting as bidentate. X-Ray diffraction patterns of the complex were different from that of the ligand suggesting formation of coordination compounds. The method is quick and gives a quantatively yield, without the need for solvents or external heating. Clearly, it can present higher efficiency in terms of materials, energy and time compared to classical solution phase synthesis.

Keywords


solvent-less synthesis; cimetidine; X-Ray diffraction pattern; mechanochemistry; green chemistry

References


Cave, G. V. W.; Raston, C. L.; Scott, J. L. Chem. Commun. 2001, 2159.

Bala, M. D.; Coville, N. J. J. Organomet. Chem. 2007, 692, 709.

Mikhailanko, M. A.; Shakhtshneider, T. P.; Boldyrev, V. V. J. Malaria Science 2004, 39, 5435.

Rasmussen, M. O.; Axelsson, O.; Tanner, D. Synth. Commun. 1997, 27, 4021.

Rottenberg, G.; Downie, A. P.; Raston, C. L.; Scott, J. L. J. Am. Chem. Soc. 2001, 123, 8701.

Mashkouri, S.; Naimi-Jamal, M. R. Molecules 2009, 14, 474.

Pichon, A.; Lazuen–Garey, A.; James, S. L. Cryst. Eng. Comm. 2006, 8, 211.

Carson, C. G.; Hardcastle, K.; Schwartz, J.; Liu, X.; Hoffman, C.; Gerhardt, R. A.; Tannenbaum, R. Eur. J. Inorg. Chem. 2009, 2338.

Vuan, W.; Friscic, T.; Apperley, D.; James, S. L. Angew. Chem. Int. Ed. 2010, 49, 3916.

Braga, D.; Grespions, F.; Maini, L.; Brescello, R.; Catairea, L. Cryst. Eng. Comm. 2008, 10, 469.

Nichols, P. J.; Paston, C. L.; Steed, J. W. Chem. Commun. 2001, 1062.

Balema, V. P.; Wiench, J. W.; Prusky, M.; Percharsky, V. K. Chem. Commun. 2002, 1606.

Myers, D. J. Exotic Pet. Medicine 2006, 15, 150.

Hussain, A.; Habib, S. S. (2007). Pak. J. Physiol. 2007, 3, 8.

Penston, J.; Wormsley, G. Adverse Drugs Exp. 1986, 1, 192.

Naveh, Y.; Weis, P.; Chung, H. R.; Bogden, J. D. J. Nutri. 1987, 117, 1576.

Amigo, J. M.; Reventos, M. M.; Sancho, A.; Soto-Tuero, L.; Cantarero, A. Zeitchrift fir Kristallographie 1987, 180, 123.

Bianucci, A. M.; Dermatin, F.; Monassero, Masciocchi, M.; Ganadu, M. L.; Naldini, L.; Panzarell, A. Inorg. Chim. Acta 1991, 182, 197.

Abadia, A.; Sancho, A.; Soto, L.; Borras, J. Transition Met. Chem. 1986, 11, 8.

Kanumfre, F.; Lima, E. M.; Scheidt, G.; Carneiro, P. I. B.; Rosso, N. D. J. Braz. Chem. Soc. 2010, 21, 800.

Tella, A. C.; Isaac, A. Y.; Adeniran, R. A. International Journal of Applied Chemistry 2010, In Press.

Onoa, G. B.; Moreno, V.; Freisinger, E.; Lippert, B. J. Inorg. Biochem. 2002, 89, 237.

Lever, A. B. Inorganic Electronic Spectroscopy. Amsterdam: Elsevier, 1984.

Soto, L.; Borras, J.; Sancho, A.; Fuertes, A.; Miravitlles, C. Act. Cryst. 1985, 41, 1431.


Full Text: PDF (ENGLISH)

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

Orbital: The Electronic Journal of Chemistry (e-ISSN 1984-6428) is a quarterly scientific journal published by the Institute of Chemistry of the Universidade Federal de Mato Grosso do Sul, Brazil. Orbital is a peer-reviewed, open-access journal.