PEG-400 as an efficient and recyclable reaction medium for the synthesis of polyhydroquinolines via Hantzsch reaction

Shitole Nana Vikram, Balasaheb V. Shitole, Gopal K. Kakde, Murlidhar S. Shingare


Polyhydroquinoline derivatives have been prepared efficiently in a one-pot synthesis via Hantzsch condensation using PEG-400 as reaction medium. The present method does not involve any hazardous organic solvents or toxic catalysts. The present methodology offers several advantages such as simple procedure, excellent yields with shorter reaction times and purification of products by non-chromatographic methods.


polyhydroquinoline derivatives; Hantzsch condensation; green chemistry; PEG-400

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Orbital: The Electronic Journal of Chemistry (e-ISSN 1984-6428) is a quarterly scientific journal published by the Institute of Chemistry of the Universidade Federal de Mato Grosso do Sul, Brazil. Orbital is a peer-reviewed, open-access journal.