Ultrasound-Assisted Synthesis of 1-N-glycosyl-1H-1,2,3-Triazole Derivatives and their Anti-inflammatory Activity

Gilson Bezerra Silva, Ronaldo Nascimento de Oliveira


We have been synthesized various glycosyl triazoles from the reaction between glycosyl azide (1) and terminal alkynes (2a-g). The glycopiranosyl 1,2,3-triazoles (3-9) have been obtained in moderate-to-excellent yields (63-99%) through the copper (I)-catalyst 1,3-dipolar cycloaddition reaction at room temperature using ultrasound irradiation. In addition, preliminary anti-inflammatory tests have been performed in the compounds conjugates with benzoheterocycles (3-7) moieties that shown moderate activity


ultrasound; 1,2,3-triazole; carbohydrate; anti-inflammatory

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Orbital: The Electronic Journal of Chemistry (e-ISSN 1984-6428) is a quarterly scientific journal published by the Institute of Chemistry of the Universidade Federal de Mato Grosso do Sul, Brazil. Orbital is a peer-reviewed, open-access journal.