Selective coupling reaction between 2,6-diiodoanisoles and terminal alkynes catalyzed by Pd(PPh3)2Cl2 and CuI

Allan F. C. Rossini, Carlise Frota, Cristiano Raminelli

Abstract


The cross-coupling reaction between aryl halides and terminal alkynes, catalyzed by palladium complexes and copper (I) salts, consists in an efficient synthetic tool for the formation of C-C bonds, resulting in disubstituted acetylenic compounds. Accordingly, in this work we present our preliminary results involving the selective cross-coupling reaction between 2,6-diiodoanisoles and terminal alkynes, catalyzed by Pd(PPh3)2Cl2 and CuI, in the formation of 2-iodo-alkynylanisoles (scheme 1).

Keywords


coupling; palladium; selectivity

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Orbital: The Electronic Journal of Chemistry (e-ISSN 1984-6428) is a quarterly scientific journal published by the Institute of Chemistry of the Universidade Federal de Mato Grosso do Sul, Brazil. Orbital is a peer-reviewed, open-access journal.